Antibodies to c-met for the treatment of cancers

Details Antibodies to c-met for the treatment of cancers Antibodies to c-met for the treatment of cancers

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C12N 5/20 (2006.01) C12P 21/08 (2006.01) C12N 9/12 (2006.01)

Patent

CA 2516236

Antibodies specific for c-Met, a protein tyrosine kinase whose ligand is hepatocyte growth factor (HGF), are provided. The antibodies and fragments 5 thereof may block binding of HGF to c-Met. Antagonist antibodies can be employed to block binding of HGF to c-Met or substantially inhibit c-Met activation. The c-Met antibodies may be included in pharmaceutical compositions, articles of manufacture, or kits. Methods of treating cancer, pathological liver conditions, and ophthalmic diseases using the c-Met 10 antibodies are also provided.

L'invention concerne des anticorps spécifiques à c-Met, une protéine tyrosine kinase dont le ligand est un facteur de croissance des hépatocytes (HGF). Les anticorps et les fragments de ceux-ci peuvent bloquer la fixation de HGF à c-Met. Des anticorps antagonistes peuvent être employés pour bloquer la fixation de HGF à c-Met ou pour inhiber sensiblement l'activation de c-Met. Les anticorps contre c-Met peuvent être contenus dans des compositions pharmaceutiques, des articles fabriqués ou des kits. L'invention concerne également des méthodes de traitement du cancer, d'états hépatopatiques et de maladies ophtalmiques à l'aide des anticorps contre c-Met.

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