Antibodies to cd44 vra and methods of use

Details Antibodies to cd44 vra and methods of use Antibodies to cd44 vra and methods of use

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) C12N 5/20 (2006.01) C12N 15/13 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2532323

The present invention concerns antibodies specific for a CD44 variant protein derived from synovial cells of Rheumatoid Arthritis (RA) patients and novel cell hybridomas releasing monoclonal antibodies (mAbs) specific for said RA specific CD44 variant and mAb expressed thereby. The antibodies are useful in methods for identifying, isolating or targeting the specific CD44 variant.

La présente invention concerne des anticorps dirigés spécifiquement contre une protéine de variant de CD44 dérivée de cellules synoviales de patient souffrant de polyarthrite rhumatoïde, de nouveaux hybridomes libérant des anticorps monoclonaux dirigés spécifiquement contre ledit variant CD44 spécifique à la polyarthrite rhumatoïde, et les anticorps monoclonaux exprimés par ces hybridomes. Lesdits anticorps sont utiles dans des procédés d'identification, d'isolation ou de ciblage du variant de CD44 spécifique.

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