Antibodies to dkk-1

Details Antibodies to dkk-1 Antibodies to dkk-1

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2574881

The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

L'invention concerne des anticorps et des fragments immunologiquement fonctionnels de ceux-ci qui se lient spécifiquement aux polypeptides Dkk-1. Les anticorps et leurs fragments se lient avec une grande affinité à un épitope conformationnel situé dans la région carboxy de la protéine Dkk-1. L'invention concerne également des procédés permettant de préparer des anticorps ou des fragments ainsi que des compositions physiologiquement acceptables contenant lesdits anticorps ou fragments. L'invention concerne enfin l'utilisation de ces anticorps et fragments pour traiter des maladies variées, telles que les troubles osseux, les maladies inflammatoires, les maladies neurologiques, les maladies oculaires, les maladies rénales, les maladies pulmonaires et les maladies de la peau.

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