Antibodies to erythropoietin receptor and uses thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2563295

The present invention relates to antibodies and antigen-binding portions thereof that bind to and activate an erythropoietin receptor. The invention also relates to nucleic acid sequences encoding such antibodies and antigen- binding portions. The present invention further relates to methods of activating the endogenous activity of an erythropoietin receptor in a mammal using said antibodies and antigen-binding portions, methods of treatment, as well as pharmaceutical compositions comprising said antibodies and antigen- binding portions.

La présente invention concerne des anticorps, ainsi que leurs parties de liaison à l'antigène, qui se lient à un récepteur de l'érythropoïétine et l'activent. L'invention concerne également des séquences d'acide nucléique codant pour les anticorps et parties de liaison à l'antigène. La présente invention concerne en outre des méthodes destinées à favoriser l'activité endogène d'un récepteur de l'érythropoïétine chez un mammifère à l'aide des anticorps et parties de liaison à l'antigène, des méthodes de traitement, ainsi que des compositions pharmaceutiques comprenant les anticorps et parties de liaison à l'antigène.

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