Antibodies to human cd154

Details Antibodies to human cd154 Antibodies to human cd154

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2400106

A CD154 binding molecule, in particular an antibody to human CD154, especially a human antibody to human CD154 is provided, wherein the CDRs of the heavy chain and light chain have amino acid sequences as defined, for use in the treatment and/or prevention of diseases or disorders wherein CD154 modulation and/or interference with or inhibition of the CD154:CD40 interactions is therapeutically beneficial.

L'invention concerne une molécule de liaison CD154, notamment un anticorps anti- CD154 humain, plus spécifiquement un anticorps humain anti-CD154 humain, les CDR de la chaîne lourde et de la chaîne légère présentant des séquences d'acides aminés comme défini, pour le traitement et/ou la prévention de maladies ou de troubles. La modulation CD154 et/ou l'interférence avec les interactions CD154:CD40 ou l'inhibition desdites interactions sont bénéfiques sur le plan thérapeutique.

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