C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.108
C12N 15/00 (2006.01) C07K 14/555 (2006.01) C07K 16/24 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)
Patent
CA 1213226
Abstract There is described a collection of monoclonal anti- bodies the members of which being directed against human leucocyte interferon (HLI) which is natural or obtained by recombinant DNA technology. The mono- clonal antibodies are preferably secreted by different hybridomas. It has been shown that individual mono- clonal antibodies are not mutually inhibiting, i.e. bind together to HLI while others are mutually in- hibiting, i.e. do not bind together to HLI. It has been shown furthermore that the collection consists of groups of antibodies/members of which recognize different epitopes (antigenic determinants) of HLI. Each a member of the different groups of antibodies can be used for a solid phase-sandwich test for HLI. In addition an antibody of the collection can be used for the purification of HLI by affinity chromatography.
397155
Miggiano Vincenzo
Staehelin Theophil
Stahli Christian
Gowling Lafleur Henderson Llp
Hoffmann-La Roche Limited
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