C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
167/139, 167/42,
C12P 21/08 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2017236
ABSTRACT Polyclonal antibody from animal antiserum and monoclonal antibodies produced by hybridoma cell lines bind to a mammary cell specific growth inhibitor secreted by NHMC. When purified by affinity monoclonal antibody chromatography, the inhibitor of the present invention exhibits peaks of activity at about 47,000 and about 63,000-67,000, as measured by SDS-PAGE. The growth inhibitor is present in the sera of normal females, but is absent or present in decreased levels in the sera of normal males and female breast cancer patients. Binding assays of the antibody to the inhibitor can be used to diagnose the presence of breast cancer, to screen for those at high risk for breast cancer, and to monitor patient levels of inhibitor in mammary tissue and serum during treatment.
Cody Robert L.
Ervin Paul R. Jr.
Kaminski Mark S.
Wicha Max S.
Cody Robert L.
Ervin Paul R. Jr.
Kaminski Mark S.
Smart & Biggar
The Regents Of The University Of Michigan
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