Antibodies to human programmed death receptor pd-1

Details Antibodies to human programmed death receptor pd-1 Antibodies to human programmed death receptor pd-1

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2691357

Antibodies which block the binding of human Programmed Death Receptor 1(hPD-1) to its ligands (hPD-L1 or hPD-L2) and their variable region sequences are disclosed. A method of increasing the activity (or reducing downmodulation) of an immune response through the PD-I pathway is also disclosed.

L'invention porte sur des anticorps qui bloquent la liaison du Récepteur humain de Mort Programmée l(hPD-l) à ses ligands (hPD-Ll ou hPD-L2) et leurs séquences de région variable. L'invention porte sur un procédé d'augmentation de l'activité (ou de réduction de la modulation négative) d'une réponse immunitaire par la voie PD-I.

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