Antibodies to igf-i receptor for the treatment of cancers

Details Antibodies to igf-i receptor for the treatment of cancers Antibodies to igf-i receptor for the treatment of cancers

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01)

Patent

CA 2518980

Antibodies specific for Insulin-like growth factor I receptor (IGF-R) are provided. The antibodies and fragments thereof may block binding of IGF-I to IGF-IR. Antagonist antibodies can be employed to block binding of IGF-I to IFGF-IR or substantially inhibit IGF-IR activation. The IGF-IR antibodies may be included in pharmaceutical compositions, articles of manufacture, or kits. Methods of treating cancer using the IGF-IR antibodies are also provided.

Des anticorps spécifiques du récepteur du facteur de croissance I de type insuline (IGF-IR) sont décrits. Ces anticorps et des fragments de ceux-ci peuvent interdire la liaison de l'IGF-1 à l'IGF-IR. Des anticorps antagonistes peuvent être utilisés pour interdire la liaison de l'IGF-1 à l'IGF-IR ou inhiber sensiblement l'activation de l'IGF-IR. Les anticorps spécifiques de l'IGF-IR peuvent être incorporés dans des compositions pharmaceutiques, dans des articles fabriqués ou dans des trousses. Des procédés de traitement du cancer, des inflammations et d'états pathologiques affectant le foie, comprenant l'utilisation desdits anticorps spécifiques de l'IGF-IR, sont également décrits.

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