C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/24 (2006.01) C12N 1/19 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2688146
The present invention is directed to antibodies and fragments thereof having binding specificity for IL-6. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the VH, VL and CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-IL-6 antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-IL-6 antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-IL-6 antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with IL-6. These antibodies may bind at least one of soluble IL-6, cell surface expressed IL-6, IL-6/IL-6R and/or prevent the association of IL-6 and IL-6R, the association of IL-6/IL-6R and gp130 and or the formation of IL-6/IL-6R/gp130 multimers and thereby inhibit a biological effect associated with any of the foregoing.
L'invention concerne des anticorps et des fragments d'anticorps possédant une spécificité de liaison pour IL-6. Un autre mode de réalisation de l'invention concerne les anticorps décrits et leurs fragments de liaison comprenant les séquences des polypeptides VH, VL ET CDR décrits, ainsi que les polypeptides les codant. L'invention concerne également des conjugués d'anticorps anti-IL-6 et leurs fragments de liaison conjugués à une ou plusieurs fractions fonctionnelles ou détectables. Elle concerne également des méthodes de préparation desdits anticorps anti-IL-6 et de leurs fragments de liaison. Des modes de réalisation de l'invention concerne également l'utilisation d'anticorps anti-IL-6 et de leurs fragments de liaison à des fins de diagnostic, d'évaluation et de traitement de maladies et de troubles associés à IL-6. Ces anticorps peuvent se lier à au moins un des IL-6 suivants: IL-6 soluble, IL-6 exprimé sur la surface cellulaire, IL-6/IL-6R et/ou empêcher l'association d'IL-6 et d'IL-6R, l'association d'IL-6/IL-6R et gp130 et/ou la formation de multimères d'IL-6/IL-6R/gp130, ce qui leur permet d'inhiber un effet biologique associés à l'un ou l'autre de ces derniers.
Dutzar Ben
Garcia-Martinez Leon
Jensen Anne Elisabeth Carvalho
Kovacevich Brian
Latham John
Alder Biopharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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