Antibodies to lrp6

Details Antibodies to lrp6 Antibodies to lrp6

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 19/00 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2705923

Anti-LRP6 antibodies and antigen-binding fragments thereof, as well as pharmaceutical compositions comprising such antibodies and antigen-binding fragments are described. These anti-LRP6 antibodies can be used to enhance Wnt activity and/or antagonize Dkk1 activity. Also described are methods of therapy using such antibodies and antigen-binding regions to bind modulate Wnt/LRP6 signaling to promote tissue homeostasis, regeneration and repair in diseases such as, but not limited to, bone disorders, such as osteoporosis, rheumatoid arthritis, and osteolytic lesions caused by osteoarthritis and multiple myeloma, gas-trointestinal disease and wound healing.

L'invention concerne des anticorps anti-LRP6 et les fragments correspondants se liant à l'antigène, ainsi que des compositions pharmaceutiques comprenant de tels anticorps et fragments correspondants se liant à l'antigène. Les anticorps anti-LRP6 peuvent servir à renforcer l'activité de Wnt et/ou comme antagonistes de l'activité de Dkk1. L'invention concerne aussi des méthodes de traitement utilisant de tels anticorps et régions de liaison à l'antigène pour moduler par liaison la signalisation de Wnt/LRP6 en vue d'activer l'homéostasie tissulaire, la régénération et la réparation dans des maladies telles que, notamment, mais pas exclusivement, les troubles osseux tels que l'ostéoporose, la polyarthrite rhumatoïde et des lésions ostéolytiques provoquées par l'ostéoarthrite et le myélome multiple, une maladie gastro-intestinale et la guérison des plaies.

Affiliated with

Also associated with

Rating

Antibodies to lrp6 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibodies to lrp6, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies to lrp6 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2016098