Antibodies to nik, their preparation and use

Details Antibodies to nik, their preparation and use Antibodies to nik, their preparation and use

C - Chemistry, Metallurgy

07

K

C07K 16/40 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2541535

The present invention relates to immunoregulatory molecules. More particularly, the present invention relates to antibodies or antibody fragments capable of specifically binding NF-&kgr;B-inducing kinase (NIK)/MAP3K14, or a specific portion thereof, and to use thereof, for example for regulating a biochemical activity of NIK, and/or enabling detection of NIK or a specific portion thereof.

La présente invention concerne des molécules immunorégulatrices. L'invention porte en particulier sur des anticorps ou des fragments d'anticorps capables de se lier spécifiquement à la kinase inductrice de NF-KB (NIK)/MAP3K14, ou à une partie spécifique de cette dernière, et sur leur utilisation, par exemple pour réguler une activité biochimique de NIK, et/ou pour permettre la détection de NIK ou d'une partie spécifique de celle-ci.

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