C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 1/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2459348
The invention concerns a wide range of diseases and conditions, including cancers. The invention provides a probe for detection of such a disease or condition. The probe is able to distinguish between functional P2X7 receptors and non-functional P2X7 receptors. The probe can do this in various ways, one of which is detecting change in relation to binding of adenosine triphosphate (ATP) to the receptors. The invention also provides a method for detecting the disease or condition, using the probe. The invention extends to treatment of the disease or condition, using an antibody, or an epitope capable of generating the antibody, which can distinguish between functional and non- functional P2X7 receptors and bind to the non-functional receptors. Methods of treatment, pharmaceutical compositions and use of the probe and antibody are also included.
La présente invention concerne une grande variété de maladies et de conditions, y compris les cancers. L'invention propose une sonde destinée à la détection d'une telle maladie ou condition. La sonde est capable de distinguer entre des récepteurs fonctionnels de P2X¿7? et de récepteurs non fonctionnels de P2X¿7?. La sonde peut établir cette distinction de diverse manières, dont une consiste en la détection d'une modification par rapport à la liaison de l'adénosine triphosphate (ATP) aux récepteurs. L'invention propose également un procédé permettant la détection de la maladie ou condition, utilisant la sonde. L'invention concerne en outre un traitement de la maladie ou condition, au moyen d'un anticorps, ou d'un épitope capable de générer l'anticorps, pouvant établir la distinction entre les récepteurs fonctionnels et non fonctionnels de P2X¿7?. Enfin, l'invention concerne des procédés de traitement, des compositions pharmaceutiques et l'utilisation de la sonde et de l'anticorps
Barden Julian Alexander
Gidley-Baird Angus
Biosceptre International Limited
Intreat Pty Limited
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
LandOfFree
Antibodies to non-functional p2x7receptor, diagnosis and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Antibodies to non-functional p2x7receptor, diagnosis and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibodies to non-functional p2x7receptor, diagnosis and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1469685