A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 47/48 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 5/12 (2006.01)
Patent
CA 2491017
The present invention relates to antibodies, antibody fragments, conjugates of antibodies and antibody fragments with cytotoxic agents, and hybridomas producing the antibodies and antibody fragments, where the antibodies and antibody fragments recognize extracellular epitopes of plasma membrane proteins that are not released into the extracellular fluid, and to methods for the detection, monitoring and treatment of malignancies such as breast cancer and ovarian cancer using the antibodies, antibody fragments and conjugates.
La présente invention porte sur des anticorps, sur des conjugués d'anticorps et des fragments d'anticorps avec des agents cytotoxiques et sur des hybridomes produisant les anticorps et les fragments d'anticorps. Ces anticorps et fragments d'anticorps reconnaissent des épitopes extracellulaires des protéines de la membrane plasmique qui ne sont pas libérées dans le fluide extracellulaire. L'invention porte également sur des procédés de détection, de contrôle et de traitement de malignités telles que le cancer du sein et le cancer des ovaires au moyen des anticorps, des fragments d'anticorps et des conjugués précités.
Chittenden Thomas
Chun Philip
Goldmakher Viktor
Payne Gillian
Sneider-Mulready Kristin
Gowling Lafleur Henderson Llp
Immunogen Inc.
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