Antibodies to peptides that target git receptors and related...

Details Antibodies to peptides that target git receptors and related... Antibodies to peptides that target git receptors and related...

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) C07K 5/11 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/00 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2347700

The invention provides an antibody or antibody fragment specific to a domain of a GIT targeting agent, such as a polyclonal antibody, monoclonal antibody, chimeric antibody, single chain antibody, a Fab fragment or a Fab expression library. In particular, the invention provides an antibody or antibody fragment, wherein the GIT targeting agent is selected from the group consisting of Zelan033 (PAX2 15 mer), Zelan088(HAX42-2 20 mer) or Zelan053 (P31 D-form 16 mer). Numerous methods using these GIT targeting agent specific antibodies are disclosed.

L'invention concerne un anticorps ou fragment d'anticorps spécifique d'un domaine d'un agent ciblant le tractus gastro-intestinal tel qu'un anticorps polyclonal, un anticorps monoclonal, un anticorps chimérique, un anticorps à chaîne unique, un fragment Fab ou une banque d'expression Fab. L'invention concerne, en particulier, un anticorps ou fragment d'anticorps, l'agent ciblant le tractus gastro-intestinal étant sélectionné dans le groupe constitué de ZElan033 (15 mer PAX2), ZElan088(20 mer HAX42-2) ou ZElan053 (16 mer P31 forme D). L'invention concerne enfin de nombreuses méthodes utilisant ces anticorps spécifiques de l'agent ciblant le tractus gastro-intestinal.

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