C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/28 (2006.01) A61K 39/395 (2006.01) C07K 16/46 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2723219
The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid .beta. and advanced glycation-end-products.
La présente invention concerne des protéines isolées, notamment des anticorps monoclonaux, particulièrement des anticorps humanisés CDR-greffés, qui se lient à une protéine RAGE. Spécifiquement, ces anticorps présentent la capacité dinhiber la liaison dun RAGE à ses différents ligands. Les anticorps ou des parties de ceux-ci décrits dans la présente invention sont utiles pour le traitement dune maladie ou dun trouble caractérisé par ou induit par des ligands physiopathologiques des RAGE, par exemple des protéines mal pliées telles que lamyloïde ß et les produits terminaux de glycation avancée.
Digiammarino Enrico L.
Ebert Ulrich
Fox Gerard B.
Gu Jijie
Harlan John E.
Abbott Gmbh & Co. Kg.
Abbott Laboratories
Torys Llp
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