A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/40 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2533503
Monoclonal and polyclonal antibodies are provided which can bind to the FbsA protein of Streptococcus agalactiae (GBS) and which can be used to prevent adherence of the bacteria to host cells and thus be useful in the treatment and protection against infection from S. agalactiae. The antibodies of the invention can also be raised against the fibrinogen binding domain of FbsA or the repeat region therein, and in addition to preventing bacterial adherence, the antibodies to FbsA are advantageous in that they can be used to prevent platelet aggregation and thrombus formation.
La présente invention a trait à des anticorps monoclonaux et polyclonaux capables de se lier à la protéine FbsA de Streptococcus agalactiae (GBS) et qui peuvent être utilisés pour la prévention d'adhérence de bactéries à des cellules hôtes et donc utiles dans le traitement et la protection contre une infection à partir de S. agalactiae. Les anticorps selon l'invention peuvent également être dirigés contre le domaine de liaison fibrinogène de FbsA ou la région de répétition s'y trouvant, et outre la prévention d'adhérence bactérienne, les anticorps à la FbsA sont avantageux en ce qu'ils peuvent être utilisés pour la prévention d'agrégation plaquettaire et de la formation de thrombus.
Pietrocola Giampiero
Speziale Pietro
Visai Livia
Blake Cassels & Graydon Llp
Universita' Degli Studi Di Pavia
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