Antibodies to truncated vegf-d and uses thereof

Details Antibodies to truncated vegf-d and uses thereof Antibodies to truncated vegf-d and uses thereof

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 39/42 (2006.01) C07K 16/24 (2006.01)

Patent

CA 2355896

The invention is based on the isolation of antibodies that were made to a polypeptide having the amino acid sequence for a truncated VEGF-D. One of these antibodies can interfere with the activity of VEGF-D mediated by VEGFR-2 and interfere with the binding of VEGF-D to VEGFR-3 but does not interfere with the activity of VEGF mediated by VEGFR-2 or bind to VEGF-C. The invention provides pharmaceutical and diagnostic compositions and methods utilizing these antibodies.

L'invention concerne l'isolement d'anticorps produits contre un polypeptide présentant la séquence d'acides aminés d'un facteur de croissance endothéliale vasculaire-D (VEGF-D) tronqué. Un de ces anticorps peut perturber l'activité du VEGF-D provoquée par le récepteur du facteur de croissance endothéliale vasculaire-2 (VEGFR-2) et perturber la liaison du VEGF-D au VEGFR-3, mais ne perturbe pas l'activité du VEGF provoqué par le VEGFR-2 ou lié au VEGF-C. L'invention concerne également des compositions à usage pharmaceutique et diagnostique ainsi que des méthodes d'utilisation de ces anticorps.

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