C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/12 (2006.01) G01N 33/543 (2006.01) G01N 33/567 (2006.01) G06F 17/00 (2006.01) G06F 19/00 (2006.01)
Patent
CA 2443903
Antibodies that specifically bind to VLA-1 integrin and methods of using these antibodies to treat immunological disorders in a subject. Also included are crystal structures of complexes formed by VLA-1 antibodies and their ligands, and VLA-1 antagonists and agonists identified by using the structure coordinates of these structures.
La présente invention concerne des anticorps qui se lient spécifiquement à l'intégrine VLA-1 et des procédés d'utilisation de ces anticorps dans le traitement d'affections immunologiques chez un sujet. L'invention se rapporte également aux structures cristallines des complexes formés par les anticorps anti-VLA-1 et leurs ligands, et à des antagonistes et agonistes de VLA-1 que l'on identifie en utilisant les coordonnées de structure de ces structures.
Garber Ellen A.
Karpusas Michael
Lyne Paul D.
Saldanha Jose W.
Biogen Inc.
Biogen Idec Ma Inc.
Gowling Lafleur Henderson Llp
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