Antibodies useable as pilot agents, and compounds containing...

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G01N 33/549 (2006.01) A61K 39/39 (2006.01) A61K 47/48 (2006.01)

Patent

CA 1289474

"ANTICORPS UTILES COMME AGENTS DE PILOTAGE ET CONJUGUES LES INCORPORANT" Invention de : SCHNEIDER Yves-Jacques, Emile ABOUD-PIRAK Esther TROUET André, Benoît, Léon IRE - CELLTARG S.A. ABREGE DESCRIPTIF L'invention concerne, à titre d'agent de pilotage de substances à activité pharmacologique et/ou à accumulation intracellulaire dans des cellules cibles, un anticorps (Ac) ou un fragment d'anticorps caractérisé en ce que : a) les antigènes (Ag) correspondants ne sont pratiquement accessibles qu'à la surface des cellules cibles, b) l'Ac ou le fragment d'Ac peut accéder aux cellules cibles, c) l'Ac ou le fragment d'Ac est endocyté et à accès aux lysosomes des cellules cibles, d) l'Ac ou le fragment d'Ac n'induit pas la disparition définitive des Ag correspondants de la surface des cellules cibles.

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