C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A01H 5/00 (2006.01) A01N 63/02 (2006.01) A61K 47/48 (2006.01) C07K 14/21 (2006.01) C07K 14/325 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 15/31 (2006.01) C12N 15/62 (2006.01) C12N 15/82 (2006.01)
Patent
CA 2193859
Antibodies, monoclonal antibodies or fragments thereof which bind to brush border membrane vesicles of insect gut and the gene or genes which encode these proteins are provided. The monoclonal antibodies bind the gut of a target insect but do not bind to mammalian brush border membranes or to plant microsomes. The antibodies and the genes encoding them find use in constructing hybrid toxins for control of insect pest.
L'invention concerne des anticorps, des anticorps monoclonaux ou des fragments de ceux-ci se fixant à des vésicules membranaires de bordure en brosse d'intestin d'insecte et le gène ou les gènes codant ces protéines. Les anticorps monoclonaux se fixent à l'intestin de l'insecte cible mais ne se fixent pas aux membranes de bordure en brosse de mammifères ou aux microsomes végétaux. Les anticorps et les gènes les codant trouvent une utilisation dans l'élaboration de toxines hybrides destinées à la lutte contre les insectes parasites.
Carozzi Nadine Barbara
Koziel Michael Gene
Ag Ciba-Geigy
Fetherstonhaugh & Co.
LandOfFree
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