Antibodies with altered binding to fcrn and methods of using...

Details Antibodies with altered binding to fcrn and methods of using... Antibodies with altered binding to fcrn and methods of using...

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C12N 15/13 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2726845

This invention relates to antibodies with altered binding to FcRn, and particularly antibodies having enhanced binding to FcRn and/or enhanced serum half-lives. The invention also relates to methods of using the antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease.

L'invention concerne des anticorps à liaison altérée à FcRn,plus précisément des anticorps présentant une liaison renforcée à FcRn et/ou des demi-vies sériques renforcées. L'invention concerne également des procédés d'utilisation des anticorps et des compositions les comprenant lors du diagnostic, du pronostic et de la thérapie de maladies telles que cancer, maladies auto-immunes, troubles inflammatoires et maladie infectieuse.

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