C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/46 (2006.01) A61K 39/21 (2006.01) C07K 16/10 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2623517
Antibodies and method of making antibodies, either monoclonal or polyclonal wherein said antibodies have dual or multi-specific binding capacity to more than one type of antigenic epitope. The antibodies have simultaneous or independent recognition subsites to each of the epitopes. Antigenic epitopes include lipids, peptides, proteins, amino acid sequences, sugars and carbohydrates. Monoclonal antibodies and a method of making monoclonal antibodies of the invention include monoclonal antibodies that are broadly neutralizing to HIV-I or other envelop viruses wherein the monoclonal antibody has subsites that simultaneously recognize protein and lipid epitopes from the virus.
L'invention concerne des anticorps et des méthodes de fabrication de ces anticorps. Ces anticorps sont soit monoclonaux ou polyclonaux. Ces anticorps présentent une capacité de liaison multispécifique à au moins un type d'épitope antigénique. Ces anticorps présentent des sous-sites de reconnaissance simultanée ou indépendante se rapportant à chaque épitope. Les épitopes antigéniques de l'invention comprennent des lipides, des peptides, des protéines, des séquences d'acides aminés, des sucres et des glucides. L'invention concerne des anticorps monoclonaux et une méthode de fabrication de ces anticorps monoclonaux. Ces anticorps comprennent des anticorps monoclonaux qui neutralisent largement HIV-I ou d'autres virus à enveloppe. Ces anticorps monoclonaux présentent des sous-sites qui reconnaissent simultanément des épitopes protéiniques et lipidiques provenant du virus.
Alving Carl R.
Marks & Clerk
Walter Reed Army Institute Of Research (wrair)
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