Antibodies with specificity for multiple adhesion molecules

Details Antibodies with specificity for multiple adhesion molecules Antibodies with specificity for multiple adhesion molecules

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/18 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2134966

The present invention involves monoclonal antibodies which recognize a common determinant found on separate and distinct adhesion molecules. The monoclonal antibodies are used for blocking cellular adhesion. Monoclonal antibodies are also described that are capable of binding to a common determinant expressed on separate and distinct selectins and in particular antibodies that bind to both E-selectin (also known as ELAM-1) and L-selectin (also known as LAM-I, LECAM-1, Leu-8, TQ-1, gp 90 MEL-14 and peripheral lymph node homing receptor). The monoclonal antibodies are useful in the diagnosis; treatment and prevention of diseases associated with inflammation. The monoclonal antibodies are used for detecting cells bearing selectins. Cell lines capable of producing the above described antibodies are also described.

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