C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
167/140, 195/1.1
C12N 5/18 (2006.01) A61K 39/42 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01)
Patent
CA 1339775
The present invention is directed to an antibody or fragment thereof, modified with a toxic substance capable of substantially inhibiting the growth of human cells infected with viruses, which is prepared by conjugating a substance capable of chemically and/or physically inducing cytotoxicity against human cells infected with HIV with an antibody or fragment thereof capable of specifically reacting with at least one antigen of said viruses, by using a pharmacologically inert substance as a carrier. The antibodies according to the present invention may be used, for example, in the diagnosis, prevention and curing of chronic disorders induced by viral infections, e.g AIDS and leukemia, since they are not only capable of inhibiting the growth of the virus-producing cells and capable of killing such cells but also are capable of neutralizing the viruses without inhibiting the growth of uninfected cells.
602214
Kirby Eades Gale Baker
Matsushita Shuzo
LandOfFree
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