C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 25/00 (2006.01) C07K 16/18 (2006.01)
Patent
CA 2509068
This invention relates to molecules, such as for example monoclonal antibodies or Fab fragments thereof, which are capable of binding to the human NogoA polypeptide or human NiG or human NiG- or human NogoA_623-640 with a dissociation constant < 1000nM; polynucleotides encoding such a binding molecule; an expression vector comprising such polynucleotides; the use of such a binding molecule in the treatment of nerve repair; a pharmaceutical composition comprising such a binding molecule; and to a method of treatment of diseases associated with nerve repair.
L'invention concerne des molécules, notamment par exemple, des anticorps monoclonaux ou des fragments Fab de ceux-ci, pouvant se lier au polypeptide NogoA humain ou à NiG humain ou à NiG_623-640 humain ou à NogoA_623-640 humain, avec une constante de dissociation inférieure à 1000 nM. L'invention concerne des polynucléotides codant une telle molécule de liaison ; un vecteur d'expression comprenant ces polynucléotides ; l'utilisation d'une telle molécule de liaison dans le traitement d'une réparation nerveuse ; une composition pharmaceutique comprenant une telle molécule de liaison ; et une méthode de traitement de maladies associées à une réparation nerveuse.
Barske Carmen
Mir Anis Khusro
Oertle Thomas
Schnell Lisa
Schwab Martin E.
Fetherstonhaugh & Co.
Novartis Ag
Universitaet Zuerich
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