Antibody against carcinoembryonic antigen (cea)

Details Antibody against carcinoembryonic antigen (cea) Antibody against carcinoembryonic antigen (cea)

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/00 (2006.01) C07K 16/06 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01)

Patent

CA 2177584

The invention provides an antibody specific for carcinoembryonic antigen (CEA) which has a dissociation constant (Kd) of less than 5.0 nM for said antigen. The antibody is generally a single chain Fv (scFv) antibody. The antibody was initially obtained by screening a bacteriophage library for phage expressing high affinity CEA antibody. The antibody is useful for diagnosis and therapeutic treatment of colorectal tumours.

L'invention se rapporte à un anticorps spécifique de l'antigène carcino-embryonnaire (CEA) qui présente une constante de dissociation (Kd) dudit antigène inférieure à 5,0 nM. Cet anticorps est généralement un anticorps à chaîne simple Fv (scFv). On a initialement obtenu cet anticorps par criblage d'une bibliothèque de bactériophages afin qu'un phage exprime un anticorps présentant une affinité élevée à l'égard de l'antigène carcino-embryonnaire (CEA). Cet anticorps est utile dans le diagnostic et le traitement thérapeutique des tumeurs colo-rectales.

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