Antibody against human interleukin-5 receptor .alpha. chain

Details Antibody against human interleukin-5 receptor .alpha. chain Antibody against human interleukin-5 receptor .alpha. chain

C - Chemistry, Metallurgy

12

N

C12N 5/18 (2006.01) A61K 39/395 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/85 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2205007

The present invention provides monoclonal antibodies and humanized antibodies which react specifically with a human interleukin-5 receptor a chain. The invention also provides hybridomas and transformants which produce the antibodies, the monoclonal antibodies and humanized antibodies, a method for detecting an interleukin-5 receptor a chain immunologically by means of these antibodies, as well as a method for diagnosing and treating diseases such as chronic bronchial asthma by means of the monoclonal antibodies and humanized antibodies. The present invention is useful for diagnosis or treatment of diseases such as chronic bronchial asthma.

L'invention concerne un anticorps monoclonal qui se lie spécifiquement sur la chaîne alpha du récepeteur de l'interleukine 5 humaine; un anticorps humanisé; un hybridome et un transformant produisant l'anticorps; un procédé de repérage immunologique de l'anticorps monoclonal, de l'anticorps humanisé et, en outre, de la chaîne alpha du récepteur de l'interleukine 5 humaine au moyen de ces anticorps; et un procédé de diagnostic et de traitement pour la bronchite chronique, entre autres, par le biais des anticorps monoclonal et humanisé en question.

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