C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/02 (2006.01) A61K 31/7105 (2006.01) A61K 35/12 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/53 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2536911
[PROBLEMS] To provide a method of diagnosing caner with the use of Nox1 gene relating to mutated Ras oncogen, a method of screening a cancer growth inhibitor and a medicinal composition to be used in treating cancer. [MEANS FOR SOLVING PROBLEMS] A polypeptide encoded by Nox1 gene, its homolog, a composition for producing an antibody containing such a peptide fragment, an antibody against the polypeptide encoded by Nox1 gene, and a method of detecting mRNA expressing such an antibody or Nox1.
La présente invention concerne la recherche d'une méthode de diagnostic du cancer dans laquelle on utilise le gène Nox1 relatif à l'oncogène Ras muté, d'une méthode de criblage d'un inhibiteur de croissance du cancer et d'une composition thérapeutique destinée à être utilisée dans le traitement du cancer. On a trouvé un polypeptide codé par le gène Nox1, son homologue, une composition utile pour produire un anticorps contenant un tel fragment peptidique, un anticorps dirigé contre le polypeptide codé par le gène Nox1 et une méthode de détection de l'ARNm exprimant un tel anticorps ou Nox1.
Hirose Kunitaka
Kamata Toru
Mitsushita Junji
Kamata Toru
Kureha Corporation
Mitsushita Junji
Sim & Mcburney
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