C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 19/00 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 19/00 (2006.01) C12N 15/02 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2667263
It is intended to provide a monoclonal antibody which specifically recognizes RGD in the amino acid sequence of human and mouse extracellular matrix proteins. By specifically inhibiting the adhesion mediated by the RGD sequence, it is expected that efficacious effects can be exerted on diseases such as inflammation, cancer, infection, autoimmunity and osteoporosis and side effects can be relieved at the same time. Thus, an improved therapy for these diseases can be provided.
L'invention concerne un anticorps monoclonal qui reconnaît spécifiquement RGD dans la séquence d'acides aminés de protéines de matrice extracellulaire humaine et de souris. Par l'inhibition spécifique de l'adhésion par la médiation de la séquence RGD, on s'attend à ce que des effets efficaces puissent se produire dans des maladies telles que l'inflammation, le cancer, l'infection, l'auto-immunité et l'ostéoporose. Des effets secondaires peuvent être soulagés en même temps. Ainsi, une thérapie améliorée pour ces maladies peut être proposée.
Kimura Chiemi
Kon Shigeyuki
Uede Toshimitsu
Borden Ladner Gervais Llp
Gene Techno Science Co. Ltd.
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