C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2497744
An antibody against solubilized glypican 3 (GPC3) whereby solubilized GPC3 in a subject sample can be detected. By detecting solubilized GPC3 in a subject sample in vitro, it can be judged whether or not the subject suffers from caner, in particular, liver cancer. Further, a cell-disrupting agent or an anticancer agent containing this antibody against GPC which can disrupt cells, in particular, cancer cells.
Un anticorps dirigé contre un glypican 3 solubilisé (GPC3), ce dernier se trouvant dans un échantillon d'un sujet, peut être détecté. Par détection de GPC3 solubilisé dans un échantillon d'un sujet in vitro, on peut juger si le sujet souffre, ou non, d'un cancer, et notamment, du cancer du foie. L'invention concerne en outre, un agent de rupture de cellule, ou un agent anticancéreux contenant cet anticorps dirigé contre GPC, capable de rompre des cellules, en particulier, des cellules cancéreuses.
Aburatani Hiroyuki
Ito Yukio
Midorikawa Yutaka
Nakano Kiyotaka
Ohizumi Iwao
Chugai Seiyaku Kabushiki Kaisha
Smart & Biggar
LandOfFree
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