Antibody and use thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 1/00 (2006.01) A61P 1/10 (2006.01) A61P 1/12 (2006.01) A61P 1/14 (2006.01) A61P 15/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C12N 5/20 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2514153

An antibody which has an extremely high avidity to human ZAQL-1, can neutralize the activity of human ZAQL-1 and inhibits the function of human ZAQL-1. Owing to these characteristics, this antibody is useful as a preventive, a remedy or a diagnostic for, e.g., digestive diseases, diseases associated with angiogenesis, diseases relating to pregnancy, eating disorder, sleeping disorder, seasonal depression, reproductive dysfunction, endocrine diseases, senile dementia, Alzheimer~s disease, various disorders caused by aging, cerebral circulatory disorder, head trauma, spinal injury, epilepsy, anxiety, depression, manic depression, schizophrenia, alcoholism, Parkinson~s disease, hypertension, arteriosclerosis, arrhythmia, premenstrual disorder syndrome, glaucoma, cancer, AIDS, diabetes, etc.

L'invention concerne un anticorps présentant une avidité extrêmement forte pour le ZAQL-1 humain, lequel anticorps peut neutraliser l'activité du ZAQL-1 humain et inhiber la fonction de ce dernier. Grâce à ces caractéristiques, ledit anticorps peut être utilisé comme agent préventif, comme remède et dans le diagnostic p. ex. de maladies digestives, de maladies associées à l'angiogenèse, de maladies associées à la grossesse, du trouble de l'alimentation, du trouble du sommeil, de la dépression saisonnière, du dysfonctionnement du système reproductif, de maladies endocriniennes, de la démence sénile, de la maladie d'Alzheimer, de divers troubles causés par le vieillissement, du trouble circulatoire cérébral, du traumatisme crânien, du traumatisme médullaire, de l'épilepsie, de l'anxiété, de la dépression, de la psychose maniacodépressive, de la schizophrénie, de l'alcoolisme, de la maladie de Parkinson, de l'hypertension, de l'artériosclérose, de l'arythmie, du syndrome prémenstruel, du glaucome, du cancer, du SIDA, du diabète, etc.

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