C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01) A61P 43/00 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2576405
It is intended to provide antibodies having a higher reactivity with amylospheroid than a reactivity with amyloid .beta.-fiber and so on. Some of these antibodies have an activity of inhibiting amylospheroid formation or an activity of inhibiting the induction of nerve cell death by amylospheroid. Such antibodies are usable in remedies/preventives for Alzheimer~s disease, screening these drugs, detecting an individual suffering from Alzheimer~s disease, reagents and so on.
La présente invention traite de l~apport d~anticorps ayant une réactivité plus grande avec la protéine .beta.-amyloïde que leur réactivité par rapport à la fibre amyloïde .beta., et plus encore. Certains de ces anticorps ont une activité d~inhibiteur de formation d~amyloïde ou une activité d~inhibiteur d~induction de la mort de cellule nerveuse par amyloïde .beta.. De tels anticorps sont utilisables dans le soin/la prévention de la maladie d'Alzheimer, dans la discrimination de ces médicaments, dans la détection d~individus souffrant de la maladie d~Alzheimer, en tant que réactifs, et plus encore.
Hoshi Minako
Ideno Shouji
Naito Koji
Fetherstonhaugh & Co.
Mitsubishi Chemical Corporation
Mitsubishi Pharma Corporation
Mitsubishi Tanabe Pharma Corporation
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