Antibody antagonists of interleukin-13 receptor .alpha.1

Details Antibody antagonists of interleukin-13 receptor .alpha.1 Antibody antagonists of interleukin-13 receptor .alpha.1

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01) C07K 14/715 (2006.01) C12N 5/16 (2006.01)

Patent

CA 2667067

Antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are useful in the inhibition of IL- 13R.alpha.1 -mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13R.alpha.1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13R.alpha.1-mediated activities are also disclosed.

La présente invention concerne des antagonistes d'anticorps du récepteur alpha 1 de l'interleukine-13 humaine. Les molécules d'anticorps sont utiles dans l'inhibition des activités induites par l'IL-13R.alpha.1 et, en conséquence, présentent des antagonistes désirables pour être utilisés dans le traitement d'états associés à l'activité de l'hIL-13R.alpha.1. La présente invention concerne également un acide nucléique codant pour lesdites molécules d'anticorps, des vecteurs, des cellules hôtes, et des compositions comprenant lesdites molécules d'anticorps. L'invention porte également sur des procédés d'utilisation de molécules d'anticorps destinées à inhiber ou contrer les activités induites par l'IL-13R.alpha.1.

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