Antibody-avidin fusion proteins as cytotoxic drugs

Details Antibody-avidin fusion proteins as cytotoxic drugs Antibody-avidin fusion proteins as cytotoxic drugs

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2471907

Methods and compositions for inducing apoptosis and/or inhibiting proliferation of cells. The method includes exposing the cells to a cytotoxic agent which is made up of a targeting moiety and an avidin moiety wherein the targeting moiety is capable of binding to one or more receptors located on the cells. The invention is based on the discovery that attaching an avidin moiety to non-toxic targeting moieties produces a cytotoxic agent which can be used to treat tumor cells both in vivo and in vitro. The present cytotoxic agent eliminates the use of biotinylated toxic drugs which previously have been conjugated to antibody-avidin targeting vehicles.

L'invention concerne des procédés et des compositions induisant l'apoptose et/ou inhibant la prolifération cellulaire. On décrit le procédé qui consiste à exposer les cellules à un agent cytotoxique constitué d'une fraction de ciblage et d'une fraction d'avidine. La fraction de ciblage peut se lier à un ou plusieurs récepteurs situés sur les cellules. La découverte fondamentale est que le fait de lier une fraction d'avidine à des fractions de ciblage non toxiques donne un agent cytotoxique susceptible d'être utilisé pour le traitement des cellules tumorales, à la fois in vivo et in vitro. La découverte de cet agent permet de renoncer à l'utilisation de médicaments toxiques biotinylés, que l'on conjuguait jusqu'à présent avec des vecteurs de ciblage anticorps-avidine.

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