C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2714413
The present inventors successfully produced monoclonal antibodies that are specific to only soluble A.beta. oligomers, but do not recognize soluble A.beta. monomers, which are physiological molecules. It was demonstrated that the antibodies are useful as diagnostic/therapeutic monoclonal antibodies for Alzheimer's disease.
L'invention porte sur un anticorps monoclonal qui ne reconnaît pas un monomère Aß soluble (une molécule physiologique) mais qui est spécifique seulement à un oligomère d'Aß soluble. Il a été observé que l'anticorps était utile comme anticorps monoclonal pour le diagnostic/traitement de la maladie d'Alzheimer.
Matsubara Etsuro
Shibata Masao
Yokoseki Tatsuki
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Immunas Pharma Inc.
Matsubara Etsuro
National Center For Geriatrics And Gerontology
Shibata Masao
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