Antibody cdr polypeptide sequences with restricted diversity

Details Antibody cdr polypeptide sequences with restricted diversity Antibody cdr polypeptide sequences with restricted diversity

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/22 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2534055

The invention provides variant CDRs comprising highly restricted amino acid sequence diversity. These polypeptides provide a flexible and simple source of sequence diversity that can be used as a source for identifying novel antigen binding polypeptides. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. Libraries comprising a plurality of these polypeptides are also provided. In addition, methods of and compositions for generating and using these polypeptides and libraries are provided.

Cette invention se rapporte à des régions CDR de polypeptides variants comprenant une diversité hautement restreinte des séquences d'acides aminés. Ces polypeptides constituent une source flexible et simple de diversité de séquences qui peut être utilisée comme source d'identification de nouveaux polypeptides de liaison d'antigènes . Cette invention concerne également ces polypeptides utilisés comme polypeptides de fusion à des polypeptides hétérologues, par exemple au moins une partie de protéines, marqueurs et segments de liaison de phages ou d'enveloppes virales. Des bibliothèques comprenant plusieurs de ces polypeptides sont également présentées. Cette invention concerne en outre des procédés et des compositions permettant de produire et d'utiliser ces polypeptides et ces bibliothèques.

Affiliated with

Also associated with

Rating

Antibody cdr polypeptide sequences with restricted diversity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Antibody cdr polypeptide sequences with restricted diversity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Antibody cdr polypeptide sequences with restricted diversity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1989602