Antibody characterization test

Details Antibody characterization test Antibody characterization test

G - Physics

01

N

G01N 33/68 (2006.01) G01N 33/536 (2006.01)

Patent

CA 2633321

The present invention relates to a method for measuring the ability of an antibody preparation to activate an Fc receptor, wherein this method comprises the following steps: a) aggregating said antibodies with one another, b) bringing cells expressing an Fc receptor into contact with said aggregated antibodies, and c) measuring the reaction of the cells resulting from the activation of the Fc receptor of said cells by the Fc region of said antibodies.

La présente invention se rapporte à un procédé pour mesurer la capacité d'une préparation d'anticorps à activer un récepteur Fc, ce procédé comprenant les étapes suivantes : a) l'agrégation desdits anticorps entre eux, b) la mise en contact de cellules exprimant un récepteur Fc avec lesdits anticorps agrégés, et c) la mesure de la réaction des cellules résultant de l'activation du récepteur Fc desdites cellules par la région Fc desdits anticorps.

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