Antibody complexes

Details Antibody complexes Antibody complexes

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2612355

This invention is directed to a soluble complex of ligands that binds to surface molecules of hemopoietic cells and result in their activation or expansion. The complex may be used in the activation and/or expansion of hemopoietic cells, optionally in combination with their transduction. The complex of ligands bind at least two cell surface molecules, such as one that plays a role in cell-cell adhesion and one that may or may not activate or stimulate the cell to promote growth and/or proliferation after binding to a ligand. A complex of ligands that bind two hemopoietic cell stimulatory molecules is also provided. The invention further provides for the use of the complex to target vectors to hemopoietic cells.

L'invention concerne un complexe soluble de ligands qui se fixe aux molécules de surface des cellules hémopoïétiques et entraîne leur activation ou expansion. Le complexe peut être utilisé dans l'activation et/ou l'expansion des cellules hémopoïétiques, éventuellement en combinaison avec leur transduction. Le complexe de ligands se fixe à au moins deux molécules de surface cellulaires, telles qu'une molécule qui joue un rôle dans l'adhésion cellule-cellule et une molécule qui peut ou non activer ou stimuler la cellule pour favoriser la croissance et/ou la prolifération après fixation à un ligand. L'invention porte également sur un complexe de ligands qui se fixe à deux molécules stimulatrices des cellules hémopoïétiques, et sur l'utilisation du complexe pour cibler des vecteurs sur des cellules hémopoïétiques.

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