C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/129, 260/299
C07D 487/14 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/06 (2006.01) A61K 51/04 (2006.01) A61K 51/10 (2006.01) C07K 16/46 (2006.01) G01N 33/531 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1282069
ABSTRACT OF THE DISCLOSURE Antibody complexes comprising hapten-modified diagnostic or therapeutic agents and anti-hapten antibodies are disclosed. Administration of hapten- modified agents such as p-bromoacetamidobenzyl EDTA(BABE)-CL232,468, BABE-Co Bleomycin and the indium complex of p-isothiocyanobenzyl EDTA linked to mitomycin C, complexed with suitable anti-hapten antibodies, extends the serum half-life and permit an increased concentration of such diagnostic or therapeutic agents at in vivo target sites.
517663
Bartholomew Richard M.
David Gary S.
Frincke James M.
Meyer Damon L.
Bartholomew Richard M.
David Gary S.
Frincke James M.
Gowling Lafleur Henderson Llp
Hybritech Incorporated
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