Antibody composition-producing cell

Details Antibody composition-producing cell Antibody composition-producing cell

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) A01K 67/00 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/06 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/32 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 9/04 (2006.01) C12N 9/10 (2006.01) C12N 9/12 (2006.01) C12N 9/88 (2006.01) C12N 9/90 (2006.01) C12N 15/52 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2424602

Cells to be used in producing antibody compositions, for example, an antibody having a high antibody-dependent cellular cytotoxic activity which is useful in various diseases, an antibody fragment or a fused protein having the Fc domain of the antibody; a process for producing an antibody composition by using these cells; antibody compositions; and uses thereof. In the above- described antibody compositions, the ratio of sugar chains, which are free from fucose bonded to N-acetylglucosamine at the sugar chain reducing end, to the total N-glycoside linkage complex sugar chains bonded to the Fc domain amounts to 20% or more. Moreover, novel GDP-mannose 4,6-dehydrogenase, GDP- keto-6-deoxymannose 3,5-epimerase 4-reductase, GDP-beta-L-fucose pyrophosphorylase, alpha-1,6-fucosyltransferase and DNAs encoding the same are provided.

L'invention concerne des cellules utilisées pour produire des compositions d'anticorps, par exemple, un anticorps à activité cytotoxique cellulaire élevée utilisé dans différentes maladies, un fragment d'anticorps ou une protéine fusionnée possédant le domaine Fc de l'anticorps, une méthode de production de compositions d'anticorps à l'aide desdites cellules, des compositions d'anticorps, et leurs utilisations. Dans ces compositions, le pourcentage de chaînes sucre exemptes de fucose liées à la N-acétylglucosamine au niveau de l'extrémité de réduction de chaîne sucre par rapport à la totalité des chaînes sucre complexes à liaison N-glycoside liées au domaine Fc s'élève à 20 % ou plus. L'invention concerne également de nouvelles GDP-mannose 4,6-déhydrogénase, GDP-céto-6-déoymannose 3,5-épimérase 4-réductase, GDP-béta-L-fucose pyrophosphorylase, alpha-1,6-fucosyltransférase et leurs ADN.

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