Antibody composition specifically binding to ganglioside gm2

Details Antibody composition specifically binding to ganglioside gm2 Antibody composition specifically binding to ganglioside gm2

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2548787

There has been required an anti-ganglioside GM2 antibody composition which has an enhanced effector function and is useful as a drug. Thus it is intended to provide a composition comprising an antibody molecule which specifically binds to ganglioside GM2 and has an N-glycoside-binding complex sugar chain in its Fc domain, wherein the N-glycoside-binding complex sugar chain is a sugar chain having no fucose attached to N-acetylglucosamine at the reducing end of the sugar chain; a transformant producing this antibody composition; a process for producing the antibody composition; and a drug containing the antibody composition.

La présente invention concerne une composition d'anticorps anti-ganglioside GM2 qui possède une fonction effectrice améliorée et qui convient comme médicament. Cette invention concerne une composition comprenant une molécule anticorps qui se lie spécifiquement au ganglioside GM2 et qui possède une chaîne de sucre complexe se liant à N-glycoside dans son domaine Fc, cette chaîne de sucre complexe se à N-glycoside étant une chaîne de sucre ne possède pas de fucose fixé à N-acétylglucosamine à l'extrémité de réduction de cette chaîne de sucre. Cette invention concerne aussi un intermédiaire produisant cette composition anticorps, un processus de production de cette composition anticorps et un médicament contenant cette composition anticorps.

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