Antibody composition specifically binding to il-5 receptor

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2542042

It is intended to provide a composition comprising an antibody molecule which specifically binds to human interleukin-5 receptor (IL-5R) .alpha. chain and has an N-glycoside-binding complex sugar chain in the Fc domain, wherein the N- glycoside-binding complex sugar chain is a sugar chain having no fucose attached to N-acetylglucosamine at the reducing end of the sugar chain; a transformant producing this antibody composition; a process for producing the antibody composition; and a drug containing the antibody composition.

La présente invention concerne une composition comprenant une molécule d'anticorps qui se lie spécifiquement à la chaîne alpha du récepteur humain de l'interleukine 5 (IL-5) et présente une chaîne glucidique complexe se liant au N-glycoside dans le domaine Fc. Ladite chaîne glucidique étant une chaîne glucidique ne présentant aucun fucose relié à la N-acétylglucosamine à son extrémité de réduction. Cette invention concerne également un transformant permettant de produire une telle composition d'anticorps ; un procédé permettant de produire la composition d'anticorps, ainsi qu'un médicament contenant cette composition d'anticorps.

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