A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/139, 167/44
A61K 39/395 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) G01N 33/531 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01)
Patent
CA 1203164
ABSTRACT OF THE DISCLOSURE Methods for covalently attaching soluble or insoluble conjugate partners (compounds, linkers or supports) to antibody molecules to form antibody conjugates useful in affinity purification, separation, diagnostic and therapeutic applications. Conjugate partners are attached to (a) carbohydrate moietites of antibody molecules, (b) sulfhydryl groups of antibody molecules or (c) amino or carboxy groups of the FC region of antibody molecules to provide antibody conjugates which substantially retain the immunospecificity and immunoreactivity of the antibodies from which they are made. A method is described for the covalent attachment of linker groups via amide or ester bonds to compounds which contain available amino or hydroxy groups. The linkers may be designed so that they are susceptible to cleavage by any one of the serum complement enzymes.
422609
Goers John W.f.
Lee Chyi
Mckearn Thomas J.
Rodwell John D.
Cytogen Corporation
Osler Hoskin & Harcourt Llp
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