Antibody constructs with enhanced binding affinity

Details Antibody constructs with enhanced binding affinity Antibody constructs with enhanced binding affinity

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2077348

2077348 9113166 PCTABS00007 Disclosed is an antibody construct with enhanced binding activity specific for an epitope on an antigen. The construct includes an immunoglobulin binding region of predetermined specificity and having plural hypervariable regions homologous with a hypervariable region of a native antibody specific for the epitope. The construct further includes an immunoglobulin constant region consisting essentially of a CH1 domain, a hinge, and a CH3 domain and omitting the CH2 domain normally present in a native antibody. The immunoglobulin constant region enhances the binding activity of the construct at least two fold in comparison with the binding activity of a native antibody having the same specifity.

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