Antibody containing igg2 having amino acid mutation...

Details Antibody containing igg2 having amino acid mutation... Antibody containing igg2 having amino acid mutation...

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2759146

The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al); has an agonist activity; and binds to human CD40.

L'invention porte sur un anticorps monoclonal ayant une activité agoniste et capable de se lier à CD40 humain. De façon spécifique, l'invention porte sur un anticorps monoclonal ayant une activité agoniste et capable de se lier au CD40 humain, qui a une région constante de chaîne lourde qui est IgG2 dans laquelle au moins un résidu valine en position 234, un résidu glutamine en position 237 et un résidu proline en position 331 (tels que numérotés conformément à l'indice EU dans Kabat et al.) sont substitués respectivement par un résidu alanine, un résidu alanine et un résidu sérine.

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