Antibody directed to g protein coupled receptors (gpcr)

Details Antibody directed to g protein coupled receptors (gpcr) Antibody directed to g protein coupled receptors (gpcr)

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2686238

The present invention provides an antibody directed to an epitope of a G - protein coupled receptor, wherein the antibody binds to the extracellular N - terminal region of the receptor and the binding of the antibody to the G - protein coupled receptor induces receptor internalization in cells.

La présente invention propose un anticorps dirigé contre un épitope d'un récepteur couplé à une protéine G, l'anticorps se liant à la région N-terminale extracellulaire du récepteur et la liaison de l'anticorps au récepteur couplé à la protéine G induisant une internalisation du récepteur dans les cellules.

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