Antibody-drug conjugates

Details Antibody-drug conjugates Antibody-drug conjugates

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 47/48 (2006.01) C07C 235/74 (2006.01) C07C 323/41 (2006.01) C07D 239/553 (2006.01) C07D 475/08 (2006.01) C07D 487/14 (2006.01) C07D 519/04 (2006.01) C07H 15/252 (2006.01)

Patent

CA 2119733

Abstract Immunoconjugates of antibodies or antigen- recognizing fragments of antibodies and monovalent cytotoxic drug derivatives make use of .beta.-alanine derived linkers wherein the antibody or fragment thereof is attached to the linker's carboxy group via an ester or amide group and the drug is attached through the linker's 2-position methylene group. Intermediates, compositions and methods of use also are provided.

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