Antibody-drug conjugates

Details Antibody-drug conjugates Antibody-drug conjugates

C - Chemistry, Metallurgy

07

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167/139, 260/228

C07H 15/252 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07C 235/28 (2006.01) C07H 19/04 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2000483

Abstract Conjugates of drugs and antibodies or antigen- recognizing fragments are prepared with a linker consisting of a malonate, wherein the antibody or fragment thereof is attached through a carbonyl to an ester or amide group on one of the malonate carboxyls, and the drug is linked through a methylene to the 2- position carbon of the malonate.

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