Antibody drug conjugates (adc) that bind to 24p4c12 proteins

Details Antibody drug conjugates (adc) that bind to 24p4c12 proteins Antibody drug conjugates (adc) that bind to 24p4c12 proteins

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2754531

Antibody drug conjugates (ADC's) that bind to 24P4C12 protein and variants thereof are described herein. 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.

L'invention concerne des conjugués anticorps-médicaments (ADC) qui se lient à la protéine 24P4C12 et leurs variants. La protéine 24P4C12 présente une expression tissulaire spécifique dans le tissu d'adulte normal, elle est en outre exprimé de manière aberrante dans les cancers répertoriés dans le Tableau I. En conséquence, les ADC selon l'invention offrent une composition thérapeutique pour le traitement de cancer.

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